Cancer Prognostication and Therapy

Comprehensive molecular profiling by ThyroSeq® provides pre-operative prognostication of cancerous nodules, informing the extent of surgery and therapeutic options

Based on the management guidelines from the American Thyroid Association (ATA), thyroid cancer risk stratification is important for selecting the appropriate extent of surgery (lobectomy vs total thyroidectomy), radioactive iodine (RAI) treatment, and intensity of follow-up. Most thyroid cancers are indolent and these patients are at low risk for disease recurrence after cancer removal. These patients can be treated by lobectomy and are unlikely to benefit from RAI ablation and TSH suppression. On the other hand, patients with high-risk cancers would benefit from up-front total thyroidectomy, which facilitates post-operative RAI administration and disease monitoring. ThyroSeq® provides most complete pre-operative assessment of risk of cancer recurrence in patients with thyroid nodules.

ThyroSeq® Cancer Risk Classifier (CRC)

ThyroSeq v3 Cancer Risk Classifier is developed to be used in FNAs from cytologically malignant (Bethesda VI) nodules and in resected thyroid cancers (formalin fixed paraffin-embedded (FFPE)) to assist in cancer risk stratification and patient management.  Similar to ThyroSeq v3 Genomic Classifier which  is used for nodules with indeterminate cytology (Bethesda III-V), it utilizes a next-generation sequencing of  DNA and RNA from 112 genes.  However, instead of prediction of probability of cancer in tested nodule, the main focus of the test is to predict risk of cancer recurrence required for selecting the extent of surgical management and further therapeutic options for patients with thyroid cancer. The findings are reported as Low, Intermediate or High risk of Cancer Recurrence.